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kunci jawaban buku pr matematika kelas 12 semester 1 intan pariwara
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0103
Category:Educational technologyIntroduction {#sec1-1}
============
Successful reproduction in either the domestic or the wild can be seriously jeopardized by influenza virus infections. Seasonal and pandemic influenza, as well as avian H5N1 influenza, have caused enormous economic, social, and medical problems because they can infect both humans and animals, leading to an increase in the number of susceptible hosts and high mortality rates in susceptible species such as domestic poultry and wild birds (Jamieson and Lamb [@ref15]). During a pandemic, the availability of a suitable vaccine is clearly important but unfortunately the amount of time available for producing an effective vaccine is usually very short, and even if the time is long enough, considerable effort must be devoted to developing and producing a safe and effective vaccine. Therefore, a timely and effective treatment that could be used early in an epidemic season is critical for prevention of illness and mortality.
Mx proteins are known to be excellent anti-influenza activity (Chou *et al.* [@ref7]; Liu *et al.* [@ref19]). They interfere with viral replication by inhibiting the nuclear export of viral proteins such as the matrix (M1) and nucleoprotein (N1, N2, and N3) by blocking the activity of the nuclear export proteins (Romero *et al.* [@ref23]; Bethel *et al.* [@ref5]; Chou *et al.* [@ref7]). Subsequently, there was a need for the development of new drugs for the treatment of influenza, and a novel strategy to block influenza virus is to block the function of the viral Mx proteins (Barbalace and Rice [@ref2]; Yanagi and King [@ref28]). To date, more than 500 Mx proteins have been identified, of which about 70% are in mammals and birds (Barbalace and Rice [@ref2]). It has been reported that virus with non-functional Mx proteins is not restricted by subtype Mx in mice and therefore represents a novel target for antiviral drug development (Yanagi and King [@ref28]; Furuta *et al.* [@ref10]).
A recent report showed that there is a variant of Mx-1 in old world monkeys, namely rhesus monkey (RhMx-1), that showed drug resistance against the antiviral activity of the human ortholog (our unpublished data
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